Premier "Séminaire du Pôle" sur le thème de Functional neuro-energetic and brain imaging: the power of MRS to understand how astrocytes contribute to the signal par Anne-Karine BOUZIER-SORE du Centre de Résonance Magnétique des Systèmes Biologiques de Bordeaux
Jeudi 18 octobre 2012 à 11h30, au GIN
Résumé du séminaire :
Brain possesses intrinsic mechanisms that allow the regulation of its major substrate, i.e. glucose, both for its contribution and its utilization depending on local cerebral activity variations. Despite the general recognition of this principle, the cellular and molecular mechanisms that underlie such a tight relationship between neuronal activity and energetic metabolism are still unknown and highly debated. More than 100 years ago, Camillo Golgi suggested, at the sight of their cyto-architectural connexions with endothelium cells and neurons, that astrocytes could play a central role in the distribution of energetic substrates between blood vessels and neurons. During the last 10 years, series of studies have been performed, both in vitro and in vivo, and have led to the recognition of the major role that astrocytes seem to play in brain energetic metabolism and have revealed a part of the mechanisms that come into play. Talk will focus on data obtained by NMR spectroscopy. This technique has provided results that give us a glimpse on the way astrocytes participate to neuronal energetic needs during cerebral activity.
Anne-Karine BOUZIER-SORE est biochimiste chargée de recherche au Centre de Résonance Magnétique des Systèmes Biologiques de Bordeaux (CNRS-Université Bordeaux/Segalen) ; elle est responsable de l'équipe RMN du système nerveux sain ou pathologique et travaille sur les mécanismes de couplage entre activité cérébrale et métabolisme énergétique, liens neurones et astrocyte.
Accès au séminaire : Grenoble Institut des Neurosciences, Bât. Edmond J. Safra, Chemin Fortune Ferrini CHU, La Tronche.
Arrêt de tram : Hôpital A. Michallon, à côté des urgences
On accède au Bâtiment E.J. Safra en longeant les urgences et l’entrée Chartreuse de l’Hôpital.
Stationnement possible sur le parking du restaurant universitaire Le Chantourne
